What operating systems is the mouse compatible with? Alex July 17, 2018 23:28 Updated Follow A. Windows 7, 8, 8.1, Vista, XP, Mac OS, Mac OS Mavericks and later. Requires one open USB port on computer. Related articles Can this connect using Bluetooth? Instruction Guide Can this be used to control a media player? (Play, Pause, Volume Up/Down, Next/Previous Track) Quick Guide Comments 0 comments Please sign in to leave a comment.