Yes, the USB-C Combo Hub for Desktop works when you connect it through a USB-A to USB-C adapter.

Satechi has not confirmed specific older iMac or Windows models. For Windows PCs, a Thunderbolt 4, Thunderbolt 3, USB4, or USB 3.2 Gen 2 USB-C port is required for optimal use. For the list of confirmed computers, see the Device Compatibility article.