Some e-reader apps work with the R2 Bluetooth Multimedia Remote Control, but not all are guaranteed to. When the R2 Remote is paired with an iPad in Presentation Mode, the next and previous buttons act like the right and left arrow keys on a keyboard. If your e-reader app supports keyboard navigation, it will likely work with the R2 Remote in Presentation Mode. If the app does not respond to arrow key navigation, the R2 Remote may not control it.